DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

Using yet untapped resources from moral and political philosophy, this book seeks to answer the question of whether an all good God who is presumed to be all powerful is logically compatible with the degree and amount of moral and natural evil that exists in our world. It is widely held by theists and atheists alike that it may be logically impossible for an all good, all powerful God to create a world with moral agents like ourselves that does not (...) also have at least some moral evil in it. James P. Sterba focuses on the further question of whether God is logically compatible with the degree and amount of moral and natural evil that exists in our world. The negative answer he provides marks a new stage in the age-old debate about God's existence. (shrink)

James P. Sterba offers something that philosophers have long sought: an argument showing that morality is rationally required. Furthermore he argues that morality requires substantial equality. Even libertarian perspectives, which would seem to require minimal enforcement of morality, are shown to lead to a requirement of equality.

This book conveys the breadth and interconnectedness of questions of justice - a rarity in contemporary moral and political philosophy. James P. Sterba argues that a minimal notion of rationality requires morality, and that a minimal libertarian morality requires the welfare and equal opportunity endorsee by welfare liberals and the equality endorsed by socialists, as well as a full feminist agenda. Feminist, racial, homosexual, and multicultural justice, are also shown to be mutually supporting. The author further shows the compatibility (...) between anthropocentric and biocentric environmental ethics, as between just war and pacifist theories. Finally, he spells out when normal politics, legal protest, civil disobedience, revolutionary action, and criminal disobedience are morally permitted by justice for here and now. This highly original and potentially controversial book is ideal for courses in moral and political philosophy, applied ethics, women's studies, environmental studies, and peace studies. (shrink)

I clarify a widely accepted form of contemporary naturalism and argue that supervenient physicalism should not be considered an option for those who embrace this version of naturalism. Among other things, my thesis implies that if there are insuperable difficulties for strict physicalism, then the move toward supervenience views of the mind/body problem amounts to an abandonment of this version of naturalism and not a minor adjustment of it. More precisely, my argument is this: strict physicalism excludes both substance and (...) property or event dualism. But the supervenience thesis entails some form of property or event dualism. So strict physicalism excludes the supervenience thesis. Moreover, given the nature of a widely accepted contemporary understanding of naturalism, it is best construed along strict physicalist lines and naturalists of this persuasion should not be supervenient physicalists. To make my case, I offer a characterization of a ubiquitous version of contemporary naturalism followed by an analysis of the most plausible version of supervenient physicalism consistent with this form of naturalism. I then try to show why this version of supervenient physicalism should not be an option for a naturalist of a certain persuasion. (shrink)

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This book combines the two most common approaches used to introduce students or general readers to ethics: the historical and the applied. Using these approaches, Sterba examines traditional ethical theories and disagreements, exploring Aristotelian, Kantian, and utilitarian ethics, as well as their contemporary defenders. But rather than focusing on formal aspects of these views, Sterba applies the best practical arguments from each of these perspectives to a variety of moral problems, such as sexual harassment, affirmative action, and international terrorism and (...) the second Iraqi war. (shrink)

Charles Darwin questions whether conflicts between species palpably captured by the conflict between Ichneumonidae and the caterpillars on which they prey could be compatible with the existence of an all-good, all-powerful God. He also questioned whether the suffering of millions of lower animals throughout our almost endless prehistory could be compatible with an all-good, all-powerful God. In this paper, I show that these two problems of natural evil that Darwin raised in his work can be resolved so as to present (...) no objection to theism once it is recognized what the moral principles are that should govern our relationship to the natural world and analogously should govern God’s relationship to the natural world. (shrink)

Feminism was born in controversy and it continues to flourish in controversy. The distinguished contributors to this volume provide an array of perspectives on issues including: universal values, justice and care, a feminist philosophy of science, and the relationship of biology to social theory.

We investigate the notion of relevance as it pertains to ‘commonsense’, subjunctive conditionals. Relevance is taken here as a relation between a property (such as having a broken wing) and a conditional (such as birds typically fly). Specifically, we explore a notion of ‘causative’ relevance, distinct from ‘evidential’ relevance found, for example, in probabilistic approaches. A series of postulates characterising a minimal, parsimonious concept of relevance is developed. Along the way we argue that no purely logical account of relevance (even (...) at the metalevel) is possible. Finally, and with minimal restrictions, an explicit definition that agrees with the postulates is given. (shrink)

One of the standard principles of rationality guiding traditional accounts of belief change is the principle of minimal change: a reasoner's belief corpus should be modified in a minimal fashion when assimilating new information. This rationality principle has stood belief change in good stead. However, it does not deal properly with all belief change scenarios. We introduce a novel account of belief change motivated by one of Grice's maxims of conversational implicature: the reasoner's belief corpus is modified in a minimal (...) fashion to assimilate exactly the new information. In this form of belief change, when the reasoner revises by new information p ∨ q their belief corpus is modified so that p∨q is believed but stronger propositions like p∧q are not, no matter what beliefs are in the reasoner's initial corpus. We term this conservative belief change since the revised belief corpus is a conservative extension of the original belief corpus given the new information. (shrink)

In this introduction, I summarize the main themes of my book, particularly those that my critics have focused on in their papers that follow. I also argue that I could not have reached the conclusions that I have if I hadn’t employed a peacemaking rather than a warmaking way of doing philosophy. I provide a characterization of a peacemaking way of doing philosophy and show how the conclusions of my book depend on doing philosophy in that way.

Philosophers who hold that religious considerations should play some role in public debate over fundamental issues have criticized Rawls’s ideal of public reason for being too restrictive in generally ruling out such considerations. In response, Rawls has modified his ideal so as to explicitly allow a role for religious considerations in public debate (others, such as Robert Audi, have also offered accounts of public reason along similar lines). Nevertheless, some critics of Rawls’s ideal of public reason, such as Nicholas Wolterstorff, (...) remain unsatisfied. In this paper, I will argue that once Rawls’s ideal of public reason is correctly interpreted, it will be possible to reconcile that ideal with much of the role its critics want religion to have in public debate. (shrink)

In conversation, individuals work together to achieve communicative goals, complementing and aligning language and body with each other. An important emerging question is whether interlocutors entrain with one another equally across linguistic levels (e.g., lexical, syntactic, and semantic) and modalities (i.e., speech and gesture), or whether there are complementary patterns of behaviors, with some levels or modalities diverging and others converging in coordinated fashions. This study assesses how kinematic and linguistic entrainment interact with one another across levels of measurement, and (...) according to communicative context. We analyzed data from two matched corpora of dyadic interaction between—respectively—Danish and Norwegian native speakers engaged in affiliative conversations and task‐oriented conversations. We assessed linguistic entrainment at the lexical, syntactic, and semantic level, and kinetic alignment of the head and hands using video‐based motion tracking and dynamic time warping. We tested whether—across the two languages—linguistic alignment correlates with kinetic alignment, and whether these kinetic‐linguistic associations are modulated either by the type of conversation or by the language spoken. We found that kinetic entrainment was positively associated with low‐level linguistic (i.e., lexical) entrainment, while negatively associated with high‐level linguistic (i.e., semantic) entrainment, in a cross‐linguistically robust way. Our findings suggest that conversation makes use of a dynamic coordination of similarity and complementarity both between individuals as well as between different communicative modalities, and provides evidence for a multimodal, interpersonal synergy account of interaction. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Demanding Environmental Ethics for the FutureJames P. Sterba (bio)As we contemplate the present and future effects of global climate change, it is hard not to be disillusioned by what we see. Melting glaciers, rising sea levels, more intense and erratic weather patterns, wide-scale extinction of endangered species—what can we as environmental philosophers do that might be helpful in this regard? My suggestion is that we respond by drawing (...) on the resources of traditional normative philosophy to ground a demanding environmental ethics that will justify the kind of sacrifices that are needed to cope with our unsettling future.This is a project that, with a lot of help from others, I have been working on for the last twenty years. I will present it, at least in outline, in my presidential address at the APA Central Division Meeting next spring, entitled "Completing the Kantian Project: From Rationality to Equality." By equality here I mean substantive intergenerational equality. This will require that we limit our current use of resources to simply meeting our basic needs. So the argument moves from a neutral nonmoral rational foundation to a very demanding set of practical moral requirements. So far sketched, the argument does not yet take into account the requirements that nonhuman living nature places upon us. But surprisingly, so demanding is this morality as sketched so far, that when additional considerations are introduced to take nonhuman living nature into account, not much more is required of us other thansome further constraints on population policy.Now I know some environmental philosophers are more skeptical than I am about the usefulness of traditional moral philosophy. Even I am unhappy with certain debates currently raging among contemporary moral philosophers, such as the realist/anti-realist debate. In fact, my argument is designed to make that very debate unnecessary. Still, if we leave most of traditional moral philosophy behind, what do we as philosophers bring with us to the new disciplines with which we now propose to collaborate? Do we bring an ability to do values clarification and a good sense of argument? I don't think these skills and others like them alone will be enough for the task at hand. We need a very demanding ethics, and if we don't look to philosophy to ground such an ethics, where do we look? [End Page 146]There is also an additional advantage here to grounding a demanding environmental ethics in traditional normative philosophy. Such an approach is more likely to force traditionalists and conservatives, philosophers and otherwise, to take notice of our arguments. If we are out in "left" field just talking to those both inside and outside of philosophy who happen to agree with our practical agenda, it is easier for us to be dismissed by others who are not committed to that same practical agenda. By contrast, if we address our opponents by appealing to very traditional values by which they claim to live their lives, then we do have at least a fighting chance of changing the way they do live their lives. At least, as moral philosophers, we would have then done our best to respond to the environmental crisis. Provided of course that we are also willing to reach out with our demanding ethics in hand and do that interdisciplinary collaboration that needs to be done to secure fully practical and effective solutions to the problems we face.James P. Sterba James P. Sterba is Professor of Philosophy at the University of Notre Dame. He has published 24 books, including the award-winning Justice for Here and Now (Cambridge, 1998), Three Challenges to Ethics (Oxford, 2001). Terrorism and International Justice (Oxford, 2003), Affirmative Action and Racial Preference: A Debate, co-authored with Carl Cohen (Oxford, 2003) and The Triumph of Practice Over Theory in Ethics (Oxford, 2005) He is president of the American Philosophical Association, Central Division. E-mail: [email protected] © 2007 Indiana University Press... (shrink)

This is a topically organized anthology which covers a wide range of competing positions. No other anthology offers as many competing positions under each problem and covers fourteen problems in all.

Seven important essays on the study of ancient Egyptian religion. Contents: The cosmology of the pyramid texts (James P Allen); Textual criticism in the coffin texts (David P Silverman); State and religion in the New Kingdom (Jan Assmann); The natural philosophy of Akhenaten (James P Allen); Horus or the crocodiles: a juncture of religion and magic in late Dynastic Egypt (Robert K Ritner); Psychology and society in the ancient Egyptian cult of the dead (Alan B Lloyd); Death and (...) initiation in the funerary reliion of ancient Egypt. (shrink)

In this timely collection of thoughtful and provocative essays, a diverse group of prominent philosophers and political scientists discuss critical issues such as the nature and definition of terrorism.